Informatics Publishing Limited

Snehal P. Desale ¹, Anil S. Gugle ¹, Rahul Kote ¹, Vikrant Jadhav ¹

Affiliations
1 Department of Dermatology, Venerology and Leprology, Dr. Vasantrao Pawar Medical College, Hospital, and Research Centre, Vasantdada Nagar, Adgaon, Nashik-422003, IN

Abstract

Background: Melasma, one of the common aesthetically displeasing entities, continues to be a difficult problem to treat. Chemical peeling is one new weapon in the therapeutic armamentarium of melasma. Intense Pulsed Light (IPL) is a noncoherent, broad-spectrum light, ranging from 500 to 1200 nm. Intense Pulsed Light (IPL) treatment is a good option for patients with melasma. Aims and Objective: To compare the efficacy of glycolic acid peel and intense pulsed light in the treatment of melasma. Setting: Outpatient department of Dermatology, Venerology Leprology of a tertiary health care centre with an attached medical college. Material and Methods: 60 patients of melasma were recruited in the study. Patients were randomly allocated into two groups: one group (glycolic acid 50%) and another group (IPL) with 30 patients in each group. All the participants were subjected to undergo pre-peel programme of daily application of sunscreens (day time) and 0.025% retinoic acid at bed time for two weeks in GA peel group. 4 peels were carried out at 2 weekly intervals. Four sessions of IPL were done at 3 weeks interval. MASI scoring and coloured photographs (without reavealing identity) of each patient were taken before each peel and at the end of the follow-up period i.e. 2 weeks after 4^th sitting in GA peel group and 3 weeks after 4^th sitting in IPL group. Side effects, if any, were also recorded. Statistical Analysis Used: SYSTAT version-12. Results: In both the groups there was constant decrease in MASI scores after each sitting as compared to pre-peel scores. However, the comparison of mean MASI scores i.e. both pre-peel and after each peel, between the two groups showed statistically significant difference (p<0.05). Local reactions, such as burning sensation and erythema during the peel were not significant with both the groups. Conclusions: Glycolic Acid (GA) peel (50%) is more efficacious&safe treatment modality in melasma compared to IPL.

Keywords

Glycolic Peel, Intense Pulse Light, Melasma.

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Rupinder Kaur , Anil Gugle , Rahul Kote , Vikrant Jadhav

Abstract

Background: Psoriasis is a chronic, disfiguring, inflammatory and proliferative condition of skin influenced by both genetic and environmental factors. The prevalence of psoriasis vary from 0.1% to 3% in different population1. The pathogenesis of psoriasis is interplay of various inflammatory cytokines and chemokines which play an important role in the pathogenesis of various other systemic diseases. Psoriasis has been reported to be associated with metabolic syndrome which increases the risk of Coronary Artery Disease. Aim: To study the prevalence of metabolic syndrome among patients of psoriasis vulgaris. Setting and Study Design: This is a case-control study and was conducted at the out-patient clinic of Department of Dermatology, Venereology and Leprology of a tertiary care centre. Materials and Methods: Study was approved by the Institutional ethical committee. The patients were included in two study groups. 50 patients diagnosed with psoriasis vulgaris were included as cases. Fifty age and sex matched controls were included in the control group. The detailed demographic history, duration of disease, family history and personal history was taken. Patients were assessed for severity of psoriasis using PASI score and blood sample collected was analyzed for fasting blood sugar levels and serum lipid profile. The data collected was evaluated using Chi Square test and unpaired t test. Results: Total 50 patients were included as cases and controls respectively out of which 11 (22%) were females and 39 (78%) were males. The mean age of cases and controls was 45.85 and 46.04 respectively. The mean duration of psoriasis in cases was 78.86 months. The mean PASI score was the prevalence of Metabolic Syndrome in psoriasis vulgaris was 46% in our study. Conclusion: Metabolic syndrome is a significant morbidity which predisposes the patients for Coronary Artery Disease. The patients of psoriasis vulgaris should be routinely screened for hypetension, Type II diabetes mellitus and dyslipidemias.

Keywords

Dyslipidemia, Hypertension, Metabolic Syndrome, PASI Score, Psoriasis vulgaris

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